ICU sedation, delirium & recovery
Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care
Primary result · 6MWDResult — go to the resultMedian difference 10 95% CI −75 to 84- stopped early due to slow recruitment
Authors' conclusion
Among patients with ARF, a combined intervention of early in-bed cycling and amino acid supplementation appeared safe but did not improve 6MWD or secondary outcomes during hospitalization or 6-month follow-up.
Study context
- Population
- ICU patients with acute respiratory failure (>90% mechanically ventilated)planned 128
- Participants
- 115 patients
- Comparison
- In-bed cycling plus IV amino acid plus usual care vs usual care alone
- Interventionn = 60
- Controln = 55reference
- Primary endpoint
- 6-minute walk distance (6MWD), blinded assessment
- Follow-up
- Hospital discharge
Methodological detailsmulticentre, phase 2, blinded outcome assessment, Cycling 40 ± 7 min/d (control: 0 min/d); total protein intake 1.9 ± 0.6 g/kg/d (control: 0.9 ± 0.6)
- Multicentre
- Phase 2
- Blinded outcome assessment
- Cycling 40 ± 7 min/d (control: 0 min/d); total protein intake 1.9 ± 0.6 g/kg/d (control: 0.9 ± 0.6)
Primary result
6MWD
Median difference
10
95% CI −75 to 84
P = 0.51
By group
Intervention vs Control
median difference 10 (95% CI −75 to 84); P = 0.51
As reported in the abstract
Secondary outcomes
Secondary outcomes (functional measures at ICU and hospital discharge, 6-month phone surveys)
- Similar between groups
Safety
- No evidence of safety concerns
Original publication
Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care. Am J Respir Crit Care Med. Published 13 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →