ICU sedation, delirium & recovery
Should New Data on Rehabilitation Interventions in Critically Ill Patients Change Clinical Practice? Updated Meta-Analysis of Randomized Controlled Trials
Authors' conclusion
None of the rehabilitation intervention strategies being studied influence mortality. Both mechanical ventilation and ICU stay were shortened by PPR, this strengthens the earlier findings as all new RCTs yielded very consistent results.
Study context
- Population
- Critically ill adults; Randomized controlled trials (RCTs) published January 1998 to July 20232,116 patients
- Participants
- 5,664 adults · 15 new RCTs
- Comparison
- ICU rehabilitation vs standard of care
- Outcome
- Days on mechanical ventilation, ICU and hospital LOS, and mortality
Methodological detailsupdated meta-analysis, PRISMA-guided
- Updated meta-analysis
- PRISMA-guided
Pooled result
As reported in the abstract
Exercise interventions vs Standard of careOdds ratio (CI)
Mortality; n = 53 RCTs
1.00(0.87–1.14)
Exercise interventions vs Standard of careMD, d (CI)
Duration of mechanical ventilation; n = 46
−1.76(−2.8 to −0.8 d)
- ICU LOS; n = 45
- −1.16 d (CI −2.3 to 0.0 d)
Further pooled results
| Outcome | Median (days) (95% CI) |
|---|---|
| Duration of mechanical ventilation and ICU LOS, PPR (subgroup)PPR vs Standard of care · mechanical ventilation | −1.7 (−3.2 to −0.2 d) |
| Duration of mechanical ventilation and ICU LOS, PPR (subgroup)PPR vs Standard of care · ICU LOS | −1.9 (−3.5 to −0.2 d) |
Duration of mechanical ventilation and ICU LOS, protocolized physical rehabilitation (PPR) (subgroup)
- Effects on mechanical ventilation and ICU LOS significant only for the PPR subgroup
Heterogeneity
- Newly published trials provided consistent results and reduced overall heterogeneity
Original publication
Should New Data on Rehabilitation Interventions in Critically Ill Patients Change Clinical Practice? Updated Meta-Analysis of Randomized Controlled Trials. Crit Care Med. Published 19 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →