Cardiothoracic & vascular anesthesia
Open-lung ventilation and mechanical power in thoracic surgery: Post hoc analysis of a multicentre randomised trial
Authors' conclusion
Individualisation of PEEP during OLV leads to nonclinically significant higher levels of mechanical power compared with standard PEEP. Each component of mechanical power seems to have different interactions with the occurrence of postoperative pulmonary complications.
Study context
- Population
- Thoracic surgery cases requiring one-lung ventilation (OLV)
- Participants
- 1,253 cases
- Comparison
- Open-lung ventilation vs standard positive-end expiratory pressure (PEEP)
- Open-lung ventilationn = 635
- Conventional ventilationn = 618reference
- Primary endpoint
- Composite of PPCs
- Follow-up
- Within 30 days after surgery
Primary result
As reported in the abstract
Association of mechanical power components with PPCs
Odds ratio, per J min -1 (95% CI)
Resistive component of mechanical power
1.07(1.01–1.13)
Static component of mechanical powerprotective
0.91(0.85–0.98)
Per J min −1, as printed
Further findings
| Outcome | Median difference (J min −1) (95% CI) | |
|---|---|---|
| Mechanical power, 20 min after OLV (T2) | 1.39 (0.91–1.86) | |
| Mechanical power, end of OLV (T3) | 1.27 (0.79–1.75) | |
| Mechanical power, before extubation (T4) | 2.12 (1.60–2.63) | |
| −2024Difference, J min −1 (linear scale) |
Original publication
Open-lung ventilation and mechanical power in thoracic surgery: Post hoc analysis of a multicentre randomised trial. Eur J Anaesthesiol. Published 3 September 2025. doi:10.
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