Perioperative medicine & outcomes
Intraoperative corticosteroid administration and postoperative pulmonary complications: a secondary analysis of the iPROVE clinical trials
Primary result · PPCs (weighted)Result — go to the resultOdds ratio 0.86 95% CI 0.62–1.18Authors' conclusion
Corticosteroid administration at antiemetic doses in adult patients having major abdominal or thoracic surgery was not associated with a lower incidence of postoperative pulmonary complications. Postoperative pulmonary gas exchange marginally improved in patients receiving intraoperative corticosteroids.
Study context
- Population
- Adults undergoing major abdominal or thoracic surgery, 30 hospitals
- Participants
- 1,963 adults · 2 trials
- Comparison
- Intraoperative corticosteroids at antiemetic doses vs no corticosteroids
- Corticosteroidsn = 1,142
- No corticosteroidsn = 821reference
- Primary endpoint
- Composite of PPCs
- Follow-up
- Within 30 days after surgery
Methodological detailspost hoc analysis, inverse probability of treatment weighting, multicentre
- Post hoc analysis
- Inverse probability of treatment weighting
- Multicentre
Primary result
PPCs (weighted)
Odds ratio
0.86
95% CI 0.62–1.18
P = 0.347
Corticosteroids vs No corticosteroids
OR 0.86 (95% CI 0.62–1.18); P = 0.347
As reported in the abstract
Further findings
Severe PPCs before weighting (unadjusted) · before weighting
P = 0.002
| Outcome | Adjusted mean difference (mm Hg) (95% CI) | P value | |
|---|---|---|---|
| PaO2/FiO2 ratio in PACU | 19.9 (0.64–39.1) | corrected P=0.043 | |
| −2002040Difference, mm Hg (linear scale) |
Original publication
Intraoperative corticosteroid administration and postoperative pulmonary complications: a secondary analysis of the iPROVE clinical trials. Br J Anaesth. Published 27 August 2026. doi:10.
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