Opioid administration guided by Surgical Pleth Index in patients with a combination of general and regional anaesthesia during trauma and orthopaedic surgery: a double-blind, randomised controlled trial
Authors' conclusion
SPI guided sufentanil administration did not reduce intraoperative sufentanil consumption compared to routine care in patients having trauma and orthopaedic surgery with a combination of general anaesthesia and regional anaesthesia.
Study context
- Population
- Patients with combined GA and RA undergoing trauma or orthopaedic surgery
- Participants
- 80 patients
- Comparison
- Surgical Pleth Index (SPI)-guided sufentanil administration vs routine care
- Primary endpoint
- Intraoperative sufentanil consumption
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
Intraoperative sufentanil administration adjusted to bodyweight and surgery duration
P = 0.906
Secondary outcomes
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Receiving intraoperative sufentanil | 0.909 (0.723–1.143) | P = 0.414 | |
| 0.512Relative risk (log scale) |
Morphine equivalents administered · 24 h after PACU discharge · without adjustment for multiple testing
P = 0.021
Other secondary endpoints (postoperative pain, nausea, post-anaesthesia care unit (PACU) duration, quality of recovery)
- No differences
Original publication
Opioid administration guided by Surgical Pleth Index in patients with a combination of general and regional anaesthesia during trauma and orthopaedic surgery: a double-blind, randomised controlled trial. J Clin Monit Comput. Published 3 October 2025. doi:10.
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