Perioperative medicine & outcomes
Opioid-free anaesthesia and postoperative quality of recovery: a systematic review and meta-analysis with trial sequential analysis
Pooled result · Global QoR scoreResult — go to the resultSMD 0.87 95% CI 0.48–1.27Authors' conclusion
The meta-analysis indicate OFA can improve the quality of recovery at postoperative 24 h, particularly in terms of enhancing physical comfort and reducing pain.
Study context
- Population
- Adults undergoing GA15 studies
- Comparison
- Opioid-free anaesthesia vs opioid-based anaesthesia
- Outcome
- Quality of recovery (QoR scale)
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
Global QoR score · postoperative 24 h
SMD
0.87
95% CI 0.48–1.27
OFA vs OBA
SMD 0.87 (95% CI 0.48–1.27)
As reported in the abstract
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| QoR-40 score (10 studies) · postoperative 24 h | MD 6.59 (95% CI 2.84–10.34) | |
| Global QoR-15 score (4 studies) · postoperative 24 hI2: 97%; low-level evidence; no improvement | MD 9.94 (95% CI −0.15 to 12.35) | |
| Physical comfort domainI2: 93%; moderate-level evidence | SMD 0.75 (95% CI 0.25–1.25) | |
| Pain domainI2: 91%; moderate-level evidence | SMD 0.59 (95% CI 0.15–1.03) | |
| −5051015Difference (linear scale) |
- QoR-40 score (10 studies): I2: 93%; moderate-level evidence; exceeded minimal clinically important difference of 6.3
Original publication
Opioid-free anaesthesia and postoperative quality of recovery: a systematic review and meta-analysis with trial sequential analysis. Anaesth Crit Care Pain Med. Published 11 December 2024. doi:10.
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