Effects of opioid-free total intravenous anesthesia on postoperative nausea and vomiting after treatments of lower extremity wounds: protocol for a randomized double-blind crossover trial
Study context
- Population
- Adults scheduled for at least two separate surgical treatments of lower extremity wounds under GAplanned
- Participants
- 72 adults
- Planned comparison
- Opioid-free TIVA vs opioid-based anesthesia
- Primary endpoint
- Incidence of postoperative nausea and vomiting (PONV)
- Follow-up
- First 48 h postoperatively
Methodological detailsdouble-blind, crossover, Randomised to 1 of 2 sequences (opioid-free anesthesia (OFA) then opioid-based anesthesia (OBA), or reverse); washout at least 5 days, Patients completing two procedures with designated regimens included in final analyses
- Double-blind
- Crossover
- Randomised to 1 of 2 sequences (OFA then OBA, or reverse); washout at least 5 days
- Patients completing two procedures with designated regimens included in final analyses
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Effects of opioid-free total intravenous anesthesia on postoperative nausea and vomiting after treatments of lower extremity wounds: protocol for a randomized double-blind crossover trial. Perioper Med (Lond). Published 14 July 2023. doi:10.
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