Comparison of opioid‐free and opioid‐inclusive propofol anaesthesia for thyroid and parathyroid surgery: a randomised controlled trial
Primary resultResult — go to the resultOdds ratio 0.17 95% CI 0.08–0.35Authors' conclusion
Opioid-free propofol anaesthesia reduced postoperative nausea and vomiting in patients undergoing thyroid and parathyroid surgery.
Study context
- Population
- Adults scheduled for thyroid and parathyroid surgery at two centres in mainland China; propofol titrated to BIS 45–55, PONV prophylaxis with dexamethasone and ondansetron, multimodal analgesia394 completed
- Participants
- 197 vs 197
- Comparison
- Opioid-free vs opioid-inclusive propofol anaesthesia
- Opioid-freen = 197
- Opioid-inclusiven = 197reference
- Primary endpoint
- Incidence of PONV
- Follow-up
- First 48 h after surgery
Methodological detailsdouble-blinded, two-centre, stratified by sex and trial site
- Double-blinded
- Two-centre
- Stratified by sex and trial site
Primary result
As reported in the abstract
Odds ratio
0.17
95% CI 0.08–0.35
P < 0.001
Events by treatment group
Opioid-free vs Opioid-inclusive
OR 0.17 (95% CI 0.08–0.35); P < 0.001
Further findings
Rescue anti-emetics and patient satisfaction
- Opioid-free associated with reduced need for rescue anti-emetics and higher patient satisfaction
Time to tracheal extubation
- Prolonged slightly in the opioid-free group
Postoperative pain scores and 30-day outcomes
- Similar in the two groups
Original publication
Comparison of opioid‐free and opioid‐inclusive propofol anaesthesia for thyroid and parathyroid surgery: a randomised controlled trial. Anaesthesia. Published 22 July 2024. doi:10.
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