Opioid-free anaesthesia protocol based on thoracic paravertebral block enhances postoperative recovery after breast cancer surgery: A two-center, prospective, randomized, controlled trial
Primary resultResult — go to the resultDifference 6.6 95 % CI 4.87–8.40Authors' conclusion
OFA based on TPVB improved the postoperative quality of recovery in patients undergoing breast cancer surgery.
Study context
- Population
- Patients undergoing breast cancer surgery
- Participants
- 252 patients
- Comparison
- Opioid-free anaesthesia (OFA) vs OA
- Primary endpoint
- QoR-15 score
- Follow-up
- 24 h postoperatively
Methodological detailsprospective, two-centre
- Prospective
- Two-centre
Primary result
As reported in the abstract
Difference
6.6
95 % CI 4.87–8.40
P < 0.001
By group
OFA
139.12
mean · SE 0.72
OA
132.48
mean · SE 0.84
OFA vs OA
difference 6.6 (95 % CI 4.87–8.40); P < 0.001
Secondary outcomes
Mean
| Outcome | OFA | OA |
|---|---|---|
| QoR-15 score · 48 h | 145.31 (SE 0.67) | 142.18 (SE 0.88) |
Quality of recovery (QoR-15) score · 48 h
- Higher in OFA than OA
Numerical rating scale (NRS) pain scores (resting at 6 h; active within 12 h)
- Significantly lower in OFA than OA
- P < 0.001
Time to first urination and LOS
- No statistical differences between OFA and OA
- P > 0.05
Safety
Postoperative nausea and retching
- Fewer patients in OFA
- P < 0.05
Original publication
Opioid-free anaesthesia protocol based on thoracic paravertebral block enhances postoperative recovery after breast cancer surgery: A two-center, prospective, randomized, controlled trial. J Clin Anesth. Published 17 June 2025. doi:10.
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