Opioid sparing effects of intravenous and oral acetaminophen in hip fracture patients: A population-based study
Main finding · Opioid use standardized by hospital LOSResult — go to the resultDifference 2.8% CI 2%–3.6%Authors' conclusion
In this population, IVAPAP use on the day of surgery failed to reduce opioid use or associated opioid related adverse effects when compared with oral APAP. IVAPAP was associated with increased overall costs, opioid requirements, and naloxone use.
Study context
- Population
- Patients undergoing surgery for a primary diagnosis of hip fracture, Premier Healthcare database, 2011 to 2019
- Participants
- 245,976 patients
- Exposure
- IV acetaminophen vs oral acetaminophen on the day of surgery
- IVAPAPn = 75,445
- Outcome
- Opioid utilization over the hospital stay
Methodological detailspopulation-based database, mixed effect models
- Population-based database
- Mixed effect models
Main finding
Opioid use standardized by hospital LOS
Difference
2.8%
CI 2%–3.6%
P < 0.001
IVAPAP vs APAP
difference 2.8% (CI 2%–3.6%); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (CI) | |
|---|---|---|
| Hospital costIVAPAP vs APAP · adjusted for relevant covariates | 2.7% (2.1%–3.4%) | |
| −2024Difference (linear scale) |
Safety
| Outcome | Odds (CI) | P value |
|---|---|---|
| Naloxone useIVAPAP vs APAP · higher odds with IVAPAP · adjusted for relevant covariates | 1.18 (1.1–1.27) | P < 0.001 |
Original publication
Opioid sparing effects of intravenous and oral acetaminophen in hip fracture patients: A population-based study. J Clin Anesth. Published 7 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →