Haemodynamics, fluids & transfusion
Optimal ROTEM FIBTEM Thresholds for the Identification of Hypofibrinogenemia in Cardiac Surgical Patients: An Analysis of the Influence of Increased Sensitivity on the Rate and Magnitude of False Positives
Authors' conclusion
In this study, using an A5 with 90% sensitivity to detect Clauss fibrinogen <1.5 g/L (<10 mm) had an FP rate of 25%. However, most of the FPs (80%) were <2.0 g/L.
Study context
- Population
- Cardiac surgical patients, public and private cardiothoracic surgical centres
- Participants
- 800 patients
- Comparison
- FIBTEM A5 threshold <10 mm for identifying hypofibrinogenemia
- Outcome
- Rate and magnitude of false-positive hypofibrinogenemia with an A5 threshold of sensitivity ≥0.9
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Performance
As reported in the abstract
False positives at A5 <10 mm
| Test or model | Value | Sensitivity |
|---|---|---|
| A5 <10 mm | 25% | ≥0.9 |
A5 <10 mm
Value25%
Sensitivity≥0.9
- False positives (FPs) in the range 1.5 to 2.0 g/L
- 80%
Original publication
Optimal ROTEM FIBTEM Thresholds for the Identification of Hypofibrinogenemia in Cardiac Surgical Patients: An Analysis of the Influence of Increased Sensitivity on the Rate and Magnitude of False Positives. J Cardiothorac Vasc Anesth. Published 29 August 2026. doi:10.
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