Optimization of Pharmacist Medication Management and Mortality in the Intensive Care Unit
Main finding · In-hospital mortality per one-patient increase in pharmacist-to-patient ratioResult — go to the resultOdds ratio 1.01 95% CI 1.00–1.01Authors' conclusion
Increasing pharmacist-to-patient ratios and the absence of pharmacist CMM every day were both associated with increased in-hospital mortality.
Study context
- Population
- Critically ill adults admitted to an ICU at 64 centres in the US, Jordan and Saudi Arabia, August 2023-January 2025
- Participants
- 28,795 adults · 64 centres
- Exposure
- Higher vs lower ICU pharmacist-to-patient ratio; absence vs presence of daily pharmacist comprehensive medication management (CMM)
- Outcome
- In-hospital mortality (primary exposure: pharmacist-to-patient ratio per patient, averaged over ICU stay)
Methodological details64 centres (US, Jordan, Saudi Arabia), multivariable generalized estimating equations (GEE) adjusted for clustering by centre
- 64 centres (US, Jordan, Saudi Arabia)
- Multivariable GEE adjusted for clustering by centre
Main finding
As reported in the abstract
In-hospital mortality per one-patient increase in pharmacist-to-patient ratio
Odds ratio
1.01
95% CI 1.00–1.01
P = 0.04
Each one-patient increase in pharmacist-to-patient ratio
OR 1.01 (95% CI 1.00–1.01); P = 0.04
Each one-patient increase in pharmacist-to-patient ratio, as printed
- Median (IQR) pharmacist-to-patient ratio
- 1:17 (13-23)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| In-hospital mortality, absence of pharmacist CMM for ≥1 day of ICU stay (secondary exposure)No CMM for ≥1 day vs CMM · 20% higher odds | 1.20 (1.03–1.40) | P = 0.02 | |
| Mortality by ratio category10% higher odds | 1.10 (1.00–1.22) | ||
| 0.512Odds ratio (log scale) |
Original publication
Optimization of Pharmacist Medication Management and Mortality in the Intensive Care Unit. Chest. Published 29 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →