Optimizing microbiological surveillance during selective digestive decontamination in the intensive care unit: an in silico simulation study
Authors' conclusion
Compared to twice-weekly surveillance, once-weekly microbiological surveillance reduces costs by 30% with 6% loss in clinically relevant PPM detections. No surveillance reduces costs by 60% with 14% detection loss.
Study context
- Population
- Intensive care unit (ICU) admissions receiving selective digestive decontamination (SDD), Dutch ICU
- Participants
- 8,499 ICU admissions
- Comparison
- Scenario A vs Scenario B vs Scenario C
- Outcome
- Number of clinically relevant potentially pathogenic microorganisms (PPMs) detected per scenario
Methodological detailssingle ICU data (Dutch), 52,553 clinical and 75,567 SDD cultures included
- Single ICU data (Dutch)
- 52,553 clinical and 75,567 SDD cultures included
Main finding
As reported in the abstract
Clinically relevant PPMs per 1,000 days
Clinically relevant PPMs per 1,000 days
Compared to scenario A Scenario B 94% · Scenario C 86%
Secondary outcomes
Cases of colonisation persistence per 1,000 days
| Outcome | Scenario A | Scenario B | Scenario C |
|---|---|---|---|
| Total costs of SDD surveillance per 1,000 days | €78,774 per 1,000 days | €55,208 per 1,000 days | €31,522 per 1,000 days |
- All potentially pathogenic microorganisms (PPMs) and clinically relevant subtypes, Scenario A
- 911 · 95% CI 905–917 · PPMs per 1,000 days
Original publication
Optimizing microbiological surveillance during selective digestive decontamination in the intensive care unit: an in silico simulation study. Crit Care. Published 17 June 2025. doi:10.
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