Pediatric anesthesia & critical care

Outcome following anaesthesia in infancy in the Nordic countries: Subgroup analysis of the NECTARINE study

Acta Anaesthesiol ScandPublished Secondary analysis of the NECTARINE prospective observational study

Authors' conclusion

Thirty-day morbidity and mortality data in the Nordic countries did not differ from the overall European cohort.

Study context

Population
Infants up to 60 weeks postmenstrual age (PMA) undergoing anaesthesia for surgical or non-surgical procedures in 11 Nordic centres
Participants
447 participants · 530 procedures
Comparison
Nordic cohort vs overall European NECTARINE cohort
  • Nordicn = 447
Primary endpoint
Perioperative critical events requiring intervention
Methodological detailssubgroup analysis, multicentre
  • Subgroup analysis
  • Multicentre

Primary result

As reported in the abstract

Perioperative critical events triggering interventions

Perioperative critical events triggering interventions, Nordic cohort (cases)

228 of 530

43%

Further findings

Hypotension and hypoxaemia

Hypotension
12.6%
Hypoxaemia
11.7%
More common in younger patients and those with co-morbidities

Hypo/hypercapnia

Hypocapnia (cases)
1.5%
Hypercapnia (cases)
4.7%

More than two intubation attempts

Infants requiring >2 intubation attempts (max three)
13 (2.9%)

Postoperative ICU admission

Admitted to postoperative ICU
236/530 (44.5%)

Hospital re-admissions · up to 90 days

Hospital re-admissions
98/447 = 21.9%

ASA physical status

ASA > 2; distribution similar to total European cohort
40%

Morbidity and mortality · 30 days

30-day morbidity (complications)
87/447 = 19.5%
30-day mortality
8/447, 1.8%
Did not differ from the overall European cohort

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Outcome following anaesthesia in infancy in the Nordic countries: Subgroup analysis of the NECTARINE study. Acta Anaesthesiol Scand. Published 27 March 2023. doi:10.1111/aas.14236

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