Pediatric anesthesia & critical care
Epidemiology, Morbidity and Mortality Associated With Anesthesia in Early Life: A Subgroup Analysis of the German NEonate and Children audiT of Anesthesia pRactice IN Europe (NECTARINE) Cohort
Authors' conclusion
This prospectively defined subanalysis demonstrates that perioperative outcomes and practice patterns in Germany differ from European averages, particularly regarding the frequency of critical events, thresholds for intervention, staffing ratios, and complication profiles.
Study context
- Population
- Children up to 60 weeks postmenstrual age undergoing anesthetic procedures across 165 centers in 31 European countries
- Participants
- 5,609 participants · 14 German centers
- Comparison
- German vs non-German NECTARINE cohorts
- Primary endpoint
- Incidence of perioperative critical events
Methodological detailsa priori defined national subcohort, mixed-effects logistic regression
- A priori defined national subcohort
- Mixed-effects logistic regression
Primary result
As reported in the abstract
Critical events
P < 0.001
- Cardiovascular instability most frequent critical event in German cohort
- 82.6%
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Postoperative complications after a critical event (German centers) · 30 daysCritical event vs No critical event · within German centers | 2.85 (1.67–4.87) | |
| 0.20.5125Odds ratio (log scale) |
Postoperative complications after a critical event (German centers) · 30 days
- ASA status and number of surgeries also significant predictors of morbidity
Original publication
Epidemiology, Morbidity and Mortality Associated With Anesthesia in Early Life: A Subgroup Analysis of the German NEonate and Children audiT of Anesthesia pRactice IN Europe (NECTARINE) Cohort. Paediatr Anaesth. Published 16 January 2026. doi:10.
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