Respiratory failure & ventilation
Outcomes Among Mechanically Ventilated Patients With Severe Pneumonia and Acute Hypoxemic Respiratory Failure From SARS-CoV-2 and Other Etiologies
Main finding · 90-day in-hospital mortalityResult — go to the resultOdds ratio 1.04 95% CI 0.81–1.35Authors' conclusion
In this study, mechanically ventilated patients with severe COVID-19 pneumonia had similar mortality rates as patients with other causes of severe pneumonia but longer times to liberation from mechanical ventilation.
Study context
- Population
- Adults (≥18 years) with pneumonia requiring mechanical ventilation in the first 2 weeks of hospitalization, Johns Hopkins Healthcare System
- Participants
- 719 vs 1,127
- Exposure
- COVID-19 pneumonia vs non-COVID-19 pneumonia
- COVID-19 pneumonian = 719
- non-COVID-19 pneumonian = 1,127reference
- Outcome
- In-hospital mortality
- Follow-up
- 90 days
Methodological detailspropensity score-matched, single health system
- Propensity score-matched
- Single health system
Main finding
90-day in-hospital mortality
Odds ratio
1.04
95% CI 0.81–1.35
P = 0.85
COVID-19 pneumonia vs non-COVID-19 pneumonia
OR 1.04 (95% CI 0.81–1.35); P = 0.85
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| 90-day mortality (unadjusted) · unadjusted | OR 1.21 (95% CI 1.04–1.41) | |
| Time on mechanical ventilation (unadjusted)Unadjusted | subdistribution HR 0.72 (95% CI 0.63–0.81) | |
| Liberation from mechanical ventilation (propensity score-matched)Lower rates of liberation with COVID-19 pneumonia | subdistribution HR 0.81 (95% CI 0.65–1.00) | |
| Discharged from hospital alive · 90 days | subdistribution HR 0.83 (95% CI 0.68–1.01) | |
| 0.512Ratio (log scale) |
Static respiratory system compliance (unadjusted) · lower compliance with COVID-19 pneumonia, unadjusted
P < 0.001
| Outcome | Mean difference (mL/cm H2O) (95% CI) | P value | |
|---|---|---|---|
| Respiratory system compliance (propensity score-matched) | 1.82 (−1.53 to 5.17) | P = 0.28 | |
| −50510Difference, mL/cm H2O (linear scale) |
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Ventilatory ratio (propensity score-matched) | −0.05 (−0.22 to 0.11) | P = 0.52 | |
| −0.3−0.2−0.100.10.2Difference (linear scale) |
- Static respiratory system compliance (unadjusted): values printed as "32.0 vs 28.4"; abstract states COVID-19 had lower compliance
Original publication
Outcomes Among Mechanically Ventilated Patients With Severe Pneumonia and Acute Hypoxemic Respiratory Failure From SARS-CoV-2 and Other Etiologies. JAMA Netw Open. Published 3 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →