ICU sedation, delirium & recovery
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort
Authors' conclusion
Whereas the profile of ICU-admitted HIV patients has evolved over time (HIV better controlled but more associated comorbidities), mortality risk factors remain stable, including AIDS status.
Study context
- Population
- Adult HIV patients hospitalized in intensive care unit (ICU), French university and non-university hospitals participating in the OutcomeRea database, over 24 yearsfirst ICU stays of 24,298
- Participants
- 630 patients
- Exposure
- Trends over a 24-year period among ICU-admitted HIV patients
- Outcome
- Patient profile over time
Methodological detailsmulticentre, prospective database (OutcomeRea)
- Multicentre
- Prospective database (OutcomeRea)
Main finding
As reported in the abstract
- Mean age and number of comorbidities (diabetes, renal and respiratory history, solid neoplasia) increased over time
- Proportion of HIV diagnosed on ICU admission decreased significantly; median HIV disease duration and % antiviral therapy (ART)-treated increased
- Main reasons for admission stable over time (acute respiratory distress > shock > coma)
- Significant drop in active opportunistic infection on admission; active hemopathy qualifying for AIDS increased nonsignificantly, with significant increase in anticancer chemotherapy in ICU
- Admissions for HIV-associated-non-AIDS (HANA) or non-HIV reasons stable over time
Observational data: associations, not effects.
Further findings
Predictors of 60-day mortality (multivariate analysis)
- Advanced age, chronic liver disease, past chemotherapy, SOFA > 4 at admission, hospitalization > 24 h before ICU admission, AIDS status; not period of admission
Original publication
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort. Crit Care. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →