ICU sedation, delirium & recovery
Outcomes of patients with Waldenström macroglobulinemia in intensive care unit (ICU): a retrospective multicentric study
Authors' conclusion
SOFA score and autoimmune cytopenias were most strongly associated with ICU mortality, highlighting the importance of both disease-specific complications and baseline severity
Study context
- Population
- Patients with Waldenström macroglobulinemia (WM) admitted to 6 French ICUs, 2010–2024
- Participants
- 151 patients
- Outcome
- ICU mortality (Ridge logistic regression)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
ICU mortality
ICU mortality
20%
n = 30
Higher SOFA score associated with ICU mortality (β)
0.099
Autoimmune haemolytic anemia associated with ICU mortality (β)
0.058
Hyperviscosity syndrome, strongest negative association with ICU mortality (β)
−0.045
Observational data: associations, not effects.
Further findings
WM-specific complications
- Hyperviscosity syndrome
- n = 29, 19%
- Other IgM-related vascular complications
- n = 27, 18%
Mortality · 1 year
- One-year mortality
- 40% (n = 58)
Remission in treated patients · 1 year
- Remission at one year
- 47% (n = 56)
Original publication
Outcomes of patients with Waldenström macroglobulinemia in ICU: a retrospective multicentric study. J Crit Care. Published 29 August 2026. doi:10.
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