Outcomes and prediction of mortality in patients requiring prolonged veno-arterial extracorporeal membrane oxygenation support in the PRECISE-ECLS observational study
Authors' conclusion
Patients with prolonged V-A ECMO differ in terms of indication and baseline risk scores. Mortality was not higher in patients who received ECMO support for longer than 7 days, and QoL at one year was good in both groups. Our developed multivariable prediction model showed moderate performance in predicting one-year mortality for those still on ECMO at day 7
Study context
- Population
- Patients receiving V-A ECMO for severe cardiocirculatory failure (PRECISE-ECLS)
- Participants
- 546 patients
- Exposure
- Prolonged vs short V-A ECMO support
- >7daysn = 160
- Outcome
- One-year mortality (prediction model in patients still on ECMO at day 7)
- Follow-up
- One year
Methodological detailsmulticentre, prediction model development, internal validation via bootstrapping
- Multicentre
- Prediction model development
- Internal validation via bootstrapping
Main finding
As reported in the abstract
One-year mortality
- Prediction model (age, Acute Physiology And Chronic Health Evaluation (APACHE) IV, pre-ECMO cardiac arrest, AKI during first week, cumulative Sequential Organ Failure Assessment (SOFA) and pulse pressure at day 7), internally validated: moderate performance, AUROC
- 0.68
- Prediction model Brier score
- 0.22
Observational data: associations, not effects.
Further findings
| Outcome | >7days | 1-7days |
|---|---|---|
| Health-related QoL at one year (EQ-5D index score)Median | 0.82 (IQR 0.73–0.91) | 0.82 (IQR 0.71–0.91) |
| APACHE IV score (baseline)Mean | 79 (SD 29) | 92 (SD 36) |
Health-related quality of life (QoL) at one year (EQ-5D index score)
- Comparable between both groups
APACHE IV score (baseline)
- Groups differed regarding ECMO indication
Original publication
Outcomes and prediction of mortality in patients requiring prolonged veno-arterial extracorporeal membrane oxygenation support in the PRECISE-ECLS observational study. Crit Care. Published 26 February 2026. doi:10.
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