Outpatient Treatment With Gabapentin in Women With Severe Acute Pain After Cesarean Delivery Is Ineffective: A Randomized, Double-Blind, Placebo-Controlled Trial
Primary resultResult — go to the resultHazard ratio 1.1 95% CI 0.67–1.8Authors' conclusion
Outpatient supplementation with gabapentin did not reduce time to opioid cessation, pain, anxiety, depression, fatigue, or improve physical function in women with severe pain after cesarean delivery.
Study context
- Population
- Women with at least 2 reports of severe pain after cesarean delivery resistant to standard multimodal pain management
- Participants
- 35 vs 35
- Comparison
- Outpatient gabapentin vs placebo
- Gabapentinn = 35
- Placebon = 35reference
- Primary endpoint
- Time to opioid cessation
Methodological detailsprospective, double-blind, placebo-controlled
- Prospective
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Hazard ratio
1.1
95% CI 0.67–1.8
P = 0.65
By group
Gabapentin vs Placebo
HR 1.1 (95% CI 0.67–1.8); P = 0.65
Secondary outcomes
Time to pain resolution, to discontinuation of gabapentin, acetaminophen and ibuprofen, to self-reported recovery; PROMIS anxiety, depression, fatigue, physical function
- No differences in any secondary end points between groups
Original publication
Outpatient Treatment With Gabapentin in Women With Severe Acute Pain After Cesarean Delivery Is Ineffective: A Randomized, Double-Blind, Placebo-Controlled Trial. Anesth Analg. Published 12 April 2023. doi:10.
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