Pediatric anesthesia & critical care
Oxygen Delivery During Cardiopulmonary Bypass in Pediatric Patients With Congenital Heart Disease: Association With Postoperative Acute Kidney Injury
Authors' conclusion
DO2-related values during cardiopulmonary bypass were not associated with CSA-AKI in pediatric patients with congenital heart disease. However, nadir DO2 and mean DO2 were significantly associated with postoperative serum lactate levels.
Study context
- Population
- Patients aged <15 years with congenital heart disease undergoing cardiac surgery, tertiary teaching hospital, May 2018–May 2022
- Participants
- 479 patients
- Exposure
- CSA-AKI vs no CSA-AKI, by DO2-related values during CPB
- CSA-AKIn = 147
- Outcome
- CSA-AKI occurrence
- Follow-up
- Within 48 hours postoperatively
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
CSA-AKI within 48 hours postoperatively · 48 hours postoperatively
- Developed acute kidney injury (AKI), of 479 patients
- 147 (30.7%)
- Nadir DO2, CSA-AKI vs no CSA-AKI: not significantly different
- p = 0.115
- Area under ideal DO2 (AUiDO2), CSA-AKI vs no CSA-AKI: not significantly different
- p = 0.12
- Mean DO2 significantly higher in patients with CSA-AKI
- p = 0.025
Observational data: associations, not effects.
Secondary outcomes
Maximum serum lactate (Lacmax), first 24 h after pediatric cardiac ICU admission · first 24 hours
- Nadir DO2 and mean DO2 significantly associated with Lacmax in univariate and multivariable regression
Original publication
Oxygen Delivery During Cardiopulmonary Bypass in Pediatric Patients With Congenital Heart Disease: Association With Postoperative Acute Kidney Injury. J Cardiothorac Vasc Anesth. Published 19 November 2024. doi:10.
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