Respiratory failure & ventilation
Oxygenation improvement and duration of prone positioning are associated with intensive care unit (ICU) mortality in mechanically ventilated COVID-19 patients
Authors' conclusion
In COVID-19 patients with acute respiratory failure receiving invasive mechanical ventilation and prone positioning, the physiological response to prone position is associated with ICU mortality. Prolonging the duration of the first cycle of prone position is associated with improved survival.
Study context
- Population
- Adults with COVID-19 on invasive mechanical ventilation who underwent prone positioning
- Participants
- 1,816 adults · 53 centres
- Exposure
- Physiologic response to and duration of first prone position cycle vs ICU mortality
- Outcome
- ICU mortality
Methodological detailsinternational registry, multicentre
- International registry
- Multicentre
Main finding
As reported in the abstract
- Delta-PP for PaO2/FiO2
- OR 0.48 (0.38, 0.59) (95% CI)
- Delta-PostPP for PaO2/FiO2
- OR 0.60 (0.52, 0.68) (95% CI)
- Ventilatory ratio, non-linear relationship, Delta-PP
- p = 0.022
- Ventilatory ratio, non-linear relationship, Delta-PostPP
- p = 0.004
- Delta-PP for Crs (OR, 95% CI); Delta-PostPP not associated
- 0.80 (0.65, 0.98)
- Length of first prone cycle, inverse relationship
- OR 0.82 (0.73, 0.91) (95% CI)
Observational data: associations, not effects.
Original publication
Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients. Ann Intensive Care. Published 28 January 2025. doi:10.
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