Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial
Authors' conclusion
We conclude that carbetocin is noninferior to oxytocin at elective Cesarean delivery in parturients with class III obesity, with the advantage of single bolus dosing without infusion.
Study context
- Population
- Nonlabouring, term parturients with BMI ≥ 40 kg·m-2 (class III obesity) undergoing elective Cesarean delivery under neuraxial anesthesiaincluded in the analysis
- Participants
- 47 participants
- Comparison
- Carbetocin vs Oxytocin
- Primary endpoint
- Uterine tone by obstetrician palpation (verbal numerical rating score 0 [boggy] to 10 [firm])
- Follow-up
- 3 min
Methodological detailsdouble-blind, noninferiority
- Double-blind
- Noninferiority
Primary result
As reported in the abstract
Uterine tone
Oxytocin
8
median · 95% CI 7–8
Carbetocin
8
median · 95% CI 8–9
P = 0.06
Secondary outcomes
Uterine tone · 5 and 10 min
- No difference at 5 and 10 min
Blood loss and need for additional uterotonics
- Not significantly different between groups
Safety
Side effects
- Not significantly different between groups
Original publication
Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial. Can J Anaesth. Published 6 January 2025. doi:10.
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