Respiratory failure & ventilation
P0.1 is an Unreliable Measure of Effort in Support Mechanical Ventilation in Comparison With Esophageal-Derived Measures of Effort: A Comparison Study
Authors' conclusion
The results demonstrated poor correlations between P0.1 and the other effort parameters, whereas strong correlations were observed among ΔPes, WOB, and PTP.
Study context
- Population
- Mechanically ventilated patients in spontaneous breathing (support) mode, mixed medical-surgical ICU, Leiden University Medical Center117 timeframes from 39 patient cases analysed
- Participants
- 30 participants
- Exposure
- P0.1 vs esophageal-derived measures of effort
- Outcome
- Correlation of P0.1 with esophageal-derived effort parameters
Methodological detailssingle-centre, Average values over at least three 5-minute time frames per patient
- Single-centre
- Average values over at least three 5-minute time frames per patient
Main finding
As reported in the abstract
P0.1 vs work of breathing (WOB) (poor correlation), R2
0.111
P0.1 vs pressure-time product (PTP) (poor correlation), R2
0.113
P0.1 vs ΔPes (poor correlation), R2
0.034
Observational data: associations, not effects.
Further findings
Correlations among esophageal-derived parameters
- PTP vs WOB (high correlation), R2
- 0.886
- ΔPes vs WOB (high correlation), R2
- 0.848
- ΔPes vs PTP (high correlation), R2
- 0.876
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
P0.1 is an Unreliable Measure of Effort in Support Mechanical Ventilation in Comparison With Esophageal-Derived Measures of Effort: A Comparison Study. Crit Care Med. Published 11 June 2025. doi:10.
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