Pediatric anesthesia & critical care
Paediatric perioperative hypersensitivity: the performance of the current consensus formula and the effect of uneventful anaesthesia on serum tryptase
Authors' conclusion
This is the first study suggesting the need for an adjusted formula in children to identify perioperative mast cell activation as tryptase is significantly lowered during uneventful anaesthesia.
Study context
- Population
- Children with suspected perioperative hypersensitivity (POH) from four reference centres in Belgium, France, and Denmark, and children with uneventful anaesthesia96 uneventful GA, 94 suspected POH
- Comparison
- New paediatric formula vs Current consensus formula
- Outcome
- Identification of mast cell activation in paediatric POH
Methodological detailsprospective control cohort, retrospective POH cohort, multicentre, 100 repeated five-fold cross-validation
- Prospective control cohort
- Retrospective POH cohort
- Multicentre
- 100 repeated five-fold cross-validation
Performance
As reported in the abstract
| Test or model | Sensitivity | Specificity |
|---|---|---|
| New paediatric formula | 53.2% | 96.9% |
| Current consensus formula | 31.9% | — not stated in the abstract |
Sensitivity
New paediatric formula53.2%
Current consensus formula31.9%
Specificity
New paediatric formula96.9%
Current consensus formula— not stated in the abstract
— not stated in the abstract
- New paediatric formula vs Current consensus formula: P < 0.001
Further findings
Sensitivity, subpopulation with culprit identified (subgroup)
P = 0.008
Sensitivity
Sensitivity, grade 3-4 reactions (subgroup)
P < 0.001
Sensitivity
- Internally cross-validated performance of new paediatric formula
- 53.3% · sensitivity · specificity 93.3%
Serum tryptase change during uneventful anaesthesia · 60-90 min after induction
- Median decrease in serum tryptase
- 0.41 μg L-1 (−15.9%; P<0.001)
Original publication
Paediatric perioperative hypersensitivity: the performance of the current consensus formula and the effect of uneventful anaesthesia on serum tryptase. BJA Open. Published 17 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →