Pain medicine

Pain management after major oncological breast surgery: an updated systematic review and procedure specific postoperative pain management ( PROSPECT ) recommendations

AnaesthesiaPublished Systematic review and procedure-specific recommendations

Methodological detailsPROSPECT, modified Delphi process
  • PROSPECT
  • Modified Delphi process

Recommendations

As issued by the authors

  1. Paracetamol, NSAIDs or cyclooxygenase-2 inhibitors, and dexamethasone continue to be advocated

  2. Gabapentin no longer recommended (problematic adverse effects)

  3. Single-shot ESP block; interpectoral and pectoserratus plane block; superficial serratus anterior plane block; deep serratus anterior plane block; thoracic paravertebral block; and local infiltration analgesia recommended

  4. Continuous thoracic paravertebral block no longer recommended; single-shot regional modalities suffice for the worst part of acute pain

  5. Pre- and postoperative physiotherapy recommended

  6. No perineural adjuncts, specific surgical techniques or complementary medicine therapies recommended

  7. Listed single-shot regional analgesic techniques considered equivalent to each other

Original publication

Pain management after major oncological breast surgery: an updated systematic review and procedure specific postoperative pain management ( PROSPECT ) recommendations. Anaesthesia. Published 12 August 2026. doi:10.1111/anae.70313

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