Patient preference for intraoperative opioid use and early recovery after noncardiac surgery: protocol for a randomised factorial design trial of opioid-free versus opioid-based anaesthesia (the PERFECT trial)

Gricourt, Y; Boulos, NM; Delaporte, A; Alexander, B; Besada, S; Bakhit, R; Toukhtarian, A; Neuman, I; Pearce, D; Nourian, MM; Chebishian, A; Zhou, A; Boktor, J; Mayanja, D; Grogan, T; Boldt, D; Cannesson, M; Forget, P; Joosten, A

doi:10.1016/j.bjao.2025.100420

Perioperative medicine & outcomes

Patient preference for intraoperative opioid use and early recovery after noncardiac surgery: protocol for a randomised factorial design trial of opioid-free versus opioid-based anaesthesia (the PERFECT trial)

BJA OpenPublished 18 Jun 2025Protocol for a randomised controlled trial

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Study context

Population: Adults scheduled for moderate-risk laparoscopic/robotic abdominal surgery (colorectal, urologic, gynaecologic)planned
Participants: 240 adults

Planned comparison: Opioid-free vs opioid-based anaesthesia, by patient preference or randomisation
Primary endpoint: QoR-15 score
Follow-up: POD 1

Methodological detailsinterventional, pragmatic, partially randomised, factorial, Anaesthesia providers and patients who choose their anaesthesia type unblinded

Interventional
Pragmatic
Partially randomised
Factorial
Anaesthesia providers and patients who choose their anaesthesia type unblinded

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Patient preference for intraoperative opioid use and early recovery after noncardiac surgery: protocol for a randomised factorial design trial of opioid-free versus opioid-based anaesthesia (the PERFECT trial). BJA Open. Published 18 June 2025. doi:10.1016/j.bjao.2025.100420

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