Perioperative medicine & outcomes
Preventing pulmonary complications after laparoscopic colorectal surgery: a lung-protective protocol vs. standard care: A randomised controlled trial
Primary resultResult — go to the resultHazard ratio 0.332 95% CI 0.153–0.718Authors' conclusion
Compared with traditional strategies, the integrated lung-protective approach may mitigate pulmonary complications without causing lung injury in intermediate to high-respiratory-risk patients undergoing laparoscopic colorectal surgery.
Study context
- Population
- Patients undergoing laparoscopic surgery for colorectal cancer at intermediate to high risk of pulmonary complications (ARISCAT score)
- Participants
- 120 patients
- Comparison
- Integrated lung-protective protocol vs conventional ventilation
- Primary endpoint
- Incidence of pulmonary complications
- Follow-up
- Within 30 postoperative days
Methodological detailsparallel-group, single-centre, National Cancer Centre/Cancer Hospital of the Chinese Academy of Medical Sciences, January to May 2023
- Parallel-group
- Single-centre
- National Cancer Centre/Cancer Hospital of the Chinese Academy of Medical Sciences, January to May 2023
Primary result
As reported in the abstract
Hazard ratio
0.332
95% CI 0.153–0.718
P = 0.003
By group
Lung protective vs Conventional
HR 0.332 (95% CI 0.153–0.718); P = 0.003
Secondary outcomes
Plasma biomarkers of lung injury (soluble receptor for advanced glycation end products, angiopoietin-2)
- No significant differences between the groups
Pulmonary complications by subgroup (males; aged 60 years or above)
- Lung-protective strategy conferred considerable benefits for males and individuals aged 60 years or above (treatment-by-covariate interaction analysis)
Nomogram predicting pulmonary complications (four variables)
- Strong discriminative performance; potential clinical value on decision curve analysis
Original publication
Preventing pulmonary complications after laparoscopic colorectal surgery: a lung-protective protocol vs. standard care: A randomised controlled trial. Eur J Anaesthesiol. Published 29 March 2025. doi:10.
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