Deep versus Moderate Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function: A Randomized Controlled Trial
Authors' conclusion
No evidence was found for a beneficial effect of deep NMB compared to moderate NMB in THA regarding quality of recovery or postoperative inflammation.
Study context
- Population
- Patients undergoing total hip arthroplasty
- Participants
- 100 patients
- Comparison
- Deep neuromuscular blockade (NMB) vs moderate NMB during total hip arthroplasty (THA)
- Primary endpoint
- Quality of recovery (QoR-40 questionnaire)
- Follow-up
- POD1
Methodological detailssingle-centre, blinded, Continuous or bolus administration of rocuronium
- Single-centre
- Blinded
- Continuous or bolus administration of rocuronium
Primary result
As reported in the abstract
QoR-40 score
No difference in QoR-40 score on POD1 (mean difference, deep vs moderate NMB not specified)
−4.1
95% CI −10.9 to 2.8P = .241
Secondary outcomes
| Outcome | Deep NMB | Moderate NMB | Median difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Ex vivo TNF production capacity on lipopolysaccharide stimulation · POD1Mann-Whitney U test | 1113 (IQR 651–1716) pg/mL | median 890 (IQR 532–1605) pg/mL | −125 (−440 to 155) | P = 0.34 | |
| Ex vivo IL-1β production capacity on lipopolysaccharide stimulation · POD1 | median 1386 (IQR 826–1940) pg/mL | 1148 (IQR 545–1970) pg/mL | −135 (−470 to 191) | P = 0.36 | |
| −600−400−2000200Difference (linear scale) |
Pain score at rest (NRS) · POD1
- No statistically significant difference in pain scores at rest
- MD 1.10 (99.6% CI −0.53 to 2.74), P = .049
Pain score on movement (NRS) · POD1
- No statistically significant difference in pain scores on movement
- MD 0.94 (99.6% CI −0.63 to 2.50), P = .080
Original publication
Deep versus Moderate Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function: A Randomized Controlled Trial. Anesth Analg. Published 17 July 2025. doi:10.
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