Impact of deep neuromuscular blockade on intraoperative Nociception Level (NOL)-guided remifentanil requirement during desflurane anesthesia in laparoscopic colorectal surgeries: A randomised controlled trial
Authors' conclusion
This study shows that deep neuromuscular blockade reduces intraoperative NOL-guided administration of remifentanil in colorectal laparoscopic surgeries.
Study context
- Population
- ASA I to III patients undergoing colorectal laparoscopic surgery with desflurane-remifentanil anesthesia93 analysed
- Participants
- 100 participants
- Comparison
- Deep neuromuscular block (NMB) vs Moderate NMB
- Deep NMBn = 45
- Moderate NMBn = 48reference
- Primary endpoint
- Total intraoperative remifentanil administration per hour of surgery
Methodological detailsmonocentric
- Monocentric
Primary result
As reported in the abstract
Intraoperative remifentanil administration
P < 0.001
Secondary outcomes
| Outcome | Deep NMB | Moderate NMB | P value |
|---|---|---|---|
| Lowest Leiden Surgical Rating Scale (L-SRS) | 5 (IQR 4–5) | 3 (IQR 2–5) | P < 0.001 |
| Intra-abdominal pressureMean | 11.9 (SD 1.3) | 13 (SD 1.3) | P < 0.001 |
Postoperative pain scores and analgesic administration
- Not significantly different
Original publication
Impact of deep neuromuscular blockade on intraoperative NOL-guided remifentanil requirement during desflurane anesthesia in laparoscopic colorectal surgeries: A randomised controlled trial. J Clin Anesth. Published 23 October 2024. doi:10.
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