Deep neuromuscular blockade improves surgical conditions during laparoendoscopic single-site (LESS) surgery for total hysterectomy and reduces postoperative pain: a randomized controlled trial
Authors' conclusion
Deep NMB significantly improves surgical conditions during LESS hysterectomy while reducing postoperative pain.
Study context
- Population
- Women scheduled for LESS total hysterectomy under IV anaesthesia
- Participants
- 243 women
- Comparison
- Deep neuromuscular blockade (NMB) vs moderate NMB with continuous IV cisatracurium
- Primary endpoint
- Surgical Rating Scale (SRS) score during surgery
Primary result
As reported in the abstract
SRS score
| Group | Value | Scores at lower end (1-3) | Scores at higher end (4-5) |
|---|---|---|---|
| Moderate NMB | mean 4.31 (SD 0.86) | 16.26% | |
| Deep NMB | mean 4.75 (SD 0.54) | 90.83% |
Value
Moderate NMBmean 4.31 (SD 0.86)
Deep NMBmean 4.75 (SD 0.54)
Scores at lower end (1-3)
Moderate NMB16.26%
Deep NMB— not stated in the abstract
Scores at higher end (4-5)
Moderate NMB— not stated in the abstract
Deep NMB90.83%
- Deep NMB vs Moderate NMB: P < 0.001
Secondary outcomes
| Outcome | P value |
|---|---|
| Postoperative shoulder painDecreased with deep NMB | P < 0.001 |
| VAS scores · 6/24/48 hoursLower with deep NMB | P < 0.001 |
| Morphine consumption · 72 hReduced with deep NMB | P < 0.001 |
| Time from agent withdrawal to TOFR 25%, TOFR 90% and extubationSignificantly prolonged with deep NMB | P < 0.001 |
Recovery index, post-anesthesia care unit (PACU) LOS, blood gas analysis
- No significant differences between groups
- P > 0.05
Safety
Postoperative complications incl. Postoperative nausea and vomiting (PONV) and pulmonary infection
- No significant differences between groups
- P > 0.05
Original publication
Deep neuromuscular blockade improves surgical conditions during laparoendoscopic single-site (LESS) surgery for total hysterectomy and reduces postoperative pain: a randomized controlled trial. Perioper Med (Lond). Published 28 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →