Pediatric Persistent Inflammation, Immunosuppression, and Catabolism Syndrome Prevalence in Sepsis-Related Mortalities: A 23-Year Institutional History
Authors' conclusion
Pediatric patients who died of a sepsis-related cause have a pPICS phenotype nearly one-half of the time. These patients are more likely to be in the cardiac ICU than the pediatric ICU and have associated fungal infections.
Study context
- Population
- Patients aged ≤21 years who died of culture-positive sepsis from a known source with laboratory data available, single institution, 1997–2020culture-positive sepsis
- Participants
- 557 patients
- Exposure
- pPICS vs no pPICS among sepsis-related deaths
- pPICSn = 262
- Outcome
- Prevalence of pPICS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
pPICS
47%
262
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value | |
|---|---|---|---|
| Associated fungal infection | 2.69 (95% CI 1.59–4.61) | P < 0.001 | |
| Cardiac ICU vs PICU locationMultivariate logistic regression | 3.43 (CI 1.57–7.64) | P = 0.002 | |
| 0.10.31310Odds ratio (log scale) |
Underlying comorbidities
- pPICS more likely to have underlying hematologic or oncologic disease or cardiac disease
Laboratory criteria
- Sustained absolute lymphocyte count < 1.0 × 103/μL most closely associated with pPICS
Original publication
Pediatric Persistent Inflammation, Immunosuppression, and Catabolism Syndrome Prevalence in Sepsis-Related Mortalities: A 23-Year Institutional History. Chest. Published 8 May 2023. doi:10.
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