Perioperative medicine & outcomes
Penehyclidine in the prevention of postoperative pulmonary complications in patients after general anesthesia: a systematic review and meta-analysis
Pooled resultResult — go to the resultRelative risk 0.59 95% CI 0.44–0.78Authors' conclusion
The findings of this study suggest that PHC may be associated with a reduced incidence of PPCs. PHC was also associated with lower postoperative inflammatory marker levels and improved respiratory mechanics.
Study context
- Population
- Patients undergoing GA
- Participants
- 1,313 patients · 10 randomized controlled trials (RCTs)
- Comparison
- Penehyclidine (PHC) vs control
- Outcome
- Incidence of PPCs
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
Relative risk
0.59
95% CI 0.44–0.78
P = 0.0003
PHC vs Control
RR 0.59 (95% CI 0.44–0.78); P = 0.0003
Further pooled results
Incidence of postoperative pulmonary complications (PPCs), intravenous administration (subgroup)
- Consistent results
Inflammatory marker levels and airway resistance
- Significantly reduced in the PHC group
Hospital LOS, extubation time, mortality
- No significant differences
Original publication
Penehyclidine in the prevention of postoperative pulmonary complications in patients after general anesthesia: a systematic review and meta-analysis. Perioper Med (Lond). Published 10 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →