Perfusion variables and hemodynamic phenotypes during fluid removal via net ultrafiltration in continuous renal replacement therapy: a retrospective single-center cohort study
Authors' conclusion
Impaired perfusion is highly frequent during fluid removal via net ultrafiltration.
Study context
- Population
- Critically ill adults with fluid overload on CRRT for AKI under an institutional de-resuscitation protocol (intake restriction + moderate net ultrafiltration), cardiovascular and thoracic centre1,258 measurement timepoints
- Participants
- 99 adults
- Outcome
- Occurrence of impairment in perfusion variables (mottling score, capillary refill time, arterial lactate, central venous oxygen saturation) during fluid removal via net ultrafiltration
Methodological detailssingle-centre, Included February 2021 to November 2023
- Single-centre
- Included February 2021 to November 2023
Main finding
As reported in the abstract
Impairment in ≥1 perfusion variable
Patients with impairment in ≥1 perfusion variable: Ninety-eight
98
99 %, 95 %CI 94 to 100 %
Timepoints with impairment in ≥1 perfusion variable
865
69 %, 95 %CI 66 to 71 %
Observational data: associations, not effects.
Further findings
Association of perfusion variables with mortality at day 30 (adjusted for macrohemodynamic variables)
- Cumulative mottling score > 0 the only perfusion variable associated with mortality
Hemodynamic phenotypes (hierarchical clustering on principal components)
- Three phenotypes differentiated, with significant differences in macrohemodynamic and perfusion variables
- 3
Original publication
Perfusion variables and hemodynamic phenotypes during fluid removal via net ultrafiltration in continuous renal replacement therapy: a retrospective single-center cohort study. J Crit Care. Published 15 October 2025. doi:10.
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