Perioperative medicine & outcomes
Perioperative anaphylactic reactions to central venous and pulmonary artery catheters containing chlorhexidine, sulfadiazine, or latex: a historical cohort study
Authors' conclusion
Perioperative anaphylactic reactions related to CVCs/PACs containing chlorhexidine, silver sulfadiazine, or latex were rare in this large historical cohort study.
Study context
- Population
- Adults fitted with Central Venous Catheters (CVCs)/Pulmonary Artery Catheters (PACs) at the Mayo Clinics in Minnesota, Arizona, and Florida, 1 January 2008 to 1 March 2018
- Participants
- 39,505 procedures
- Outcome
- Incidence of perioperative anaphylaxis caused by CVCs/PACs containing chlorhexidine, silver sulfadiazine, or latex
Methodological detailshistorical cohort, multicentre
- Historical cohort
- Multicentre
Main finding
As reported in the abstract
Perioperative anaphylaxis with CVCs/PACs as confirmed or potential cause
- Procedures with perioperative anaphylaxis
- 53
Observational data: associations, not effects.
Further findings
Patients with pre-existing chlorhexidine, sulfa, and/or latex allergy receiving CVCs/PACs containing these substances
- Patients
- 2,937
Preoperative allergies among anaphylaxis cases
- Preoperatively reported sulfa or latex allergy
- 7
- Preoperative chlorhexidine allergy
- 0
- Reported sulfa/latex allergy and CVC/PAC containing these substances
- 6
Postoperative allergy work-up among anaphylaxis cases
- Postoperative allergic disease consultation
- 24
- Skin testing among those consulted
- 10 (42%)
Original publication
Perioperative anaphylactic reactions to central venous and pulmonary artery catheters containing chlorhexidine, sulfadiazine, or latex: a historical cohort study. Can J Anaesth. Published 24 February 2023. doi:10.
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