Hemodynamics, fluids & transfusion
Correlation between central venous oxygen saturation and mixed venous oxygen saturation in surgical patients: A systematic review and meta-analysis
Pooled result · Interchangeability, aggregated perioperative data (10 studies, n = 524)Result — go to the resultMD −0.49 % 95% CI −1.34 to 0.35Authors' conclusion
ScvO2 is positively correlated with SvO₂ in the perioperative period. However, wide individual-level LOA indicate that the two measurements are not interchangeable in surgical patients.
Study context
- Population
- Surgical patients with paired perioperative ScvO2 and SvO2 measurements
- Participants
- 1,369 patients · 28 studies
- Comparison
- Central venous oxygen saturation vs mixed venous oxygen saturation
- Outcome
- Clinical interchangeability (pooled MD 95% CI and 95% limits of agreement both within ±5%)
Methodological detailsrandom-effects models, prespecified subgroup and sensitivity analyses
- Random-effects models
- Prespecified subgroup and sensitivity analyses
Pooled result
As reported in the abstract
Interchangeability, aggregated perioperative data (10 studies, n = 524)
MD
−0.49 %
95% CI −1.34 to 0.35
ScvO2 vs SvO₂
MD −0.49 % (95% CI −1.34 to 0.35)
- Limits of agreement (exceeded predefined ±5% threshold; not clinically interchangeable)
- −12.15% to 11.17%
Further pooled results
Pooled correlation (5 studies, n = 197)
- Pooled correlation
- 0.72 (95% CI 0.57-0.82; I² = 64.3%)
Subgroups: non-cardiovascular and off-pump procedures (subgroup)
- Narrower limits of agreement (LOA) and higher correlation in non-cardiovascular and off-pump procedures
Original publication
Correlation between central venous oxygen saturation and mixed venous oxygen saturation in surgical patients: A systematic review and meta-analysis. Ann Intensive Care. Published 12 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →