Cardiothoracic & vascular anaesthesia
Near-infrared spectroscopy for estimating mixed venous oxygen saturation and cardiac output during off-pump coronary artery bypass grafting: a prospective observational study
Authors' conclusion
Cal-rScO₂ appears to be a useful surrogate for SvO₂ trending during OPCAB after simple one-point calibration. Jugular NIRS may be useful in selected patients, whereas NIRS-based CO estimation remained clinically insufficient.
Study context
- Population
- Adults undergoing elective OPCABsingle tertiary center
- Participants
- 25 adults
- Exposure
- rSjvO₂ vs Cal-rScO₂ vs SvO₂
- Outcome
- Agreement with SvO₂ (Bland-Altman with linear mixed-effects modeling) and trending ability (error grid analysis)
Methodological detailssingle-centre, method-comparison
- Single-centre
- Method-comparison
Main finding
As reported in the abstract
Agreement with SvO₂
| Group | Bias | Limits of agreement (LoA) | AUC for SvO₂ <65% |
|---|---|---|---|
| rSjvO₂ | 2.0% | - 14.9 to 18.9% | |
| Cal-rScO₂ | 0.8% | - 7.8 to 9.4% | 0.970 |
Bias
rSjvO₂2.0%
Cal-rScO₂0.8%
Limits of agreement (LoA)
rSjvO₂- 14.9 to 18.9%
Cal-rScO₂- 7.8 to 9.4%
AUC for SvO₂ <65%
rSjvO₂— not stated in the abstract
Cal-rScO₂0.970
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| NIRS-based CO estimation (modified Fick) vs COTD | NIRS-based CO percentage error 33.0% · percentage error 95% CI 27.4 to 41.5% |
NIRS-based cardiac output (CO) estimation (modified Fick) vs COTD
- Significant proportional bias and poor trending ability
Original publication
Near-infrared spectroscopy for estimating mixed venous oxygen saturation and cardiac output during off-pump coronary artery bypass grafting: a prospective observational study. J Clin Monit Comput. Published 17 August 2026. doi:10.
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