Hemodynamics, fluids & transfusion
Central Venous Oxygen Saturation for Estimating Mixed Venous Oxygen Saturation and Cardiac Index in the ICU: A Systematic Review and Meta-Analysis
Authors' conclusion
There is moderate reliability for Scv o2 in predicting Sv o2 in critical care patients with variability based on sampling site and presence of sepsis.
Study context
- Population
- Critically ill ICU patients with ScvO2 and at least one reference standard test
- Participants
- 1,971 patients · 18 studies
- Comparison
- ScvO2 vs reference standards
- Outcome
- Agreement of ScvO2 with SvO2 (pooled ICC) and with cardiac index (Spearman correlation)
Methodological detailsindividual patient data, Searched MEDLINE, Cochrane CENTRAL and Embase to May 6, 2024; QUADAS-2 and GRADE used for risk of bias and certainty
- Individual patient data
- Searched MEDLINE, Cochrane CENTRAL and Embase to May 6, 2024; QUADAS-2 and GRADE used for risk of bias and certainty
Pooled result
As reported in the abstract
Agreement of ScvO2 with reference SvO2
Intraclass correlation coefficient (ICC)
0.83
95% CI 0.75–0.89
16 studies, 1335 patients
Mean difference
2.98 %
toward ScvO2
Further pooled results
| Outcome | Spearman rank correlation (95% CI) | P value |
|---|---|---|
| Correlation of ScvO2 with reference cardiac index (thermodilution)Scv o2 vs Thermodilution · 3 studies, 166 patients | 0.47 (0.46–0.48) | P < 0.0001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Central Venous Oxygen Saturation for Estimating Mixed Venous Oxygen Saturation and Cardiac Index in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med. Published 11 September 2024. doi:10.
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