Perioperative medicine & outcomes

Perioperative cardiac arrest and the impact of surgical timing: a nationwide cohort study

ResuscitationPublished Retrospective cohort study

Authors' conclusion

In this nationwide study, PO-CA was rare, with over half of affected patients surviving beyond 30 days. Although crude incidence appeared higher out of hours in non-cardiothoracic, non-obstetric emergency surgery, this pattern likely reflects greater patient complexity rather than out-of-hours circumstances per se.

Study context

Population
Adults (≥18 years) in the Swedish Perioperative Register, 2019–2023; timing analysis in non-cardiothoracic, non-obstetric emergency surgery
Participants
1,568,877 procedures
Exposure
Out-of-hours vs office-hours surgery
Outcome
Perioperative cardiac arrest (PO-CA: cardiac arrest in the operating theatre or PACU)
Methodological detailsnationwide, mixed-effects logistic regression
  • Nationwide
  • Mixed-effects logistic regression

Main finding

As reported in the abstract

PO-CA, non-cardiothoracic, non-obstetric emergency surgery
Out of hours vs Office hoursEstimate (95 % CI)
PO-CA, non-cardiothoracic, non-obstetric emergency surgery
crude OR 1.31(1.00–1.70)
Adjusted for sex, age, comorbidities, ASA class and case urgency
adjusted OR 1.13(0.86–1.48)

Observational data: associations, not effects.

Further findings

Perioperative cardiac arrest (PO-CA) incidence and 30-day mortality (all procedures)

PO-CA cases
395
In operating theatre
314
In post-anaesthesia care unit (PACU)
81
Crude incidence
2.5/10,000 procedures
30-day mortality after PO-CA
42.5 %

Original publication

Perioperative cardiac arrest and the impact of surgical timing: a nationwide cohort study. Resuscitation. Published 23 July 2025. doi:10.1016/j.resuscitation.2025.110737

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