Perioperative medicine & outcomes
Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial
Primary resultResult — go to the resultMean difference 2.20 95% CI 0.16–4.24Authors' conclusion
In this randomized clinical trial, psychological management and pharmacologic optimization reduced anxiety and depression in older adults undergoing surgery.
Study context
- Population
- Adults ≥60 years scheduled for cardiac, oncologic, or orthopedic surgery with clinically meaningful depression and/or anxiety symptoms (Patient Health Questionnaire-Anxiety and Depressive Symptom (PHQ-ADS)), US academic and community hospital network306 analysed
- Participants
- 326 adults
- Comparison
- Intervention vs Enhanced usual care
- Interventionn = 153
- Enhanced usual caren = 153reference
- Primary endpoint
- Change in PHQ-ADS score from baseline
- Follow-up
- 3 months after surgery
Methodological detailssingle-blind, hybrid type 1 effectiveness-implementation
- Single-blind
- Hybrid type 1 effectiveness-implementation
Primary result
As reported in the abstract
3 months
Mean difference
2.20
95% CI 0.16–4.24
P = 0.03
Intervention vs Enhanced usual care
mean difference 2.20 (95% CI 0.16–4.24); P = 0.03
Further findings
Change in PHQ-ADS score, oncologic surgery (subgroup) · 3 months
- Mean difference
- 4.93 (95% CI, 1.51-8.36; P = .005)
- Effects varied by surgical subgroups
Change in PHQ-ADS score, cardiac surgery (subgroup) · 3 months
- Mean difference
- 2.68 (95% CI, −0.98 to 6.35; P = .15)
- Effects varied by surgical subgroups
Change in PHQ-ADS score, orthopedic surgery (subgroup) · 3 months
- Mean difference
- −1.11 (95% CI, −4.62 to 2.40; P = .54)
- Effects varied by surgical subgroups
Implementability
- Patients and interventionists perceived the intervention as appropriate, with high-fidelity delivery and broad reach
Original publication
Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial. JAMA Netw Open. Published 1 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →