Perioperative medicine & outcomes
Perioperative Factor Xa Inhibitor Discontinuation for Patients Undergoing Procedures With Minimal or Low Bleeding Risk
Authors' conclusion
In this cohort study, patients with AF receiving a factor Xa inhibitor and undergoing a procedure with minimal to low bleeding risk had low rates of major bleeding and thromboembolism when following the standardized PERIXa protocol for perioperative management of oral anticoagulant treatment
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing a procedure with minimal to low bleeding risk (endoscopy, dental procedure or ocular surgery), Korea, 2020–2024modified ITT analysis set
- Participants
- 1,902 patients
- Outcome
- Major bleeding
- Follow-up
- 30 days after the index procedure
Methodological detailsmulticentre, single-arm
- Multicentre
- Single-arm
Main finding
As reported in the abstract
30 days
30-day event rate of major bleeding (n = 2)
0.1%
Observational data: associations, not effects.
Secondary outcomes
Composite thromboembolic events · 30 days
- No composite thromboembolic events
Major bleeding and thromboembolism by procedure category or factor Xa inhibitor type (subgroup)
- No differences by procedure category or factor Xa inhibitor type
Original publication
Perioperative Factor Xa Inhibitor Discontinuation for Patients Undergoing Procedures With Minimal or Low Bleeding Risk. JAMA Netw Open. Published 3 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →