Perioperative medicine & outcomes
Perioperative liberal drinking management promotes postoperative gastrointestinal function recovery after gynecological laparoscopic surgery: A randomized controlled trial
Authors' conclusion
Our primary endpoint, I-FEED score demonstrated significant reduction with perioperative liberal drinking, serving as a protective intervention against I-FEED>2.
Study context
- Population
- Patients undergoing elective gynecological laparoscopic surgery, Wuhan Union Hospital157 analysed
- Participants
- 210 patients
- Comparison
- Preoperative carbohydrate loading (PCL) with or without early oral feeding (EOF) vs control
- Primary endpoint
- Postoperative I-FEED score (range 0 to 14, higher scores worse)
Methodological detailsprospective, 3-arm 1:1:1, blinded anesthetists and follow-up staff, single-centre
- Prospective
- 3-arm 1:1:1
- Blinded anesthetists and follow-up staff
- Single-centre
Primary result
As reported in the abstract
I-FEED score
PCL
0
range 0,1
PCL-EOF
0
range 0,0
Control
1
range 0,2
- Significantly enhanced GI function recovery with PCL-EOF vs control and PCL
- P < 0.05
Secondary outcomes
| Outcome | Control | PCL | PCL-EOF | HR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| Incidence of I-FEED >2PCL-EOF vs control | 21% | 8% | 2% | 0.09 (0.01–0.72) | P = 0.023 | |
| Time to first flatusPCL-EOF vs control | 3.33 (2.14–5.19) | P < 0.001 | ||||
| Time to first defecationPCL-EOF vs control | 2.76 (1.83–4.16) | P < 0.001 | ||||
| Time to Bristol feces grade 3-4PCL-EOF vs control | 3.65 (2.36–5.63) | P < 0.001 | ||||
| Time to first fluid dietPCL-EOF vs control | 2.76 (1.83–4.16) | P < 0.001 | ||||
| Time to first normal dietPCL-EOF vs control | 6.63 (4.18–10.50) | P < 0.001 | ||||
| 0.050.21520Hazard ratio (log scale) |
Postoperative hospital LOS
Total cost
| Outcome | Control | PCL | PCL-EOF |
|---|---|---|---|
| VAS pain score · POD0 | 4 | 4 | 2 |
| VAS pain score · POD1 | 3 | 2 | 1 |
| VAS pain score · POD2 | 2 | 1 | 1 |
| VAS pain score · POD3 | — not stated in the abstract | 1 | — not stated in the abstract |
— not stated in the abstract
- Postoperative hospital LOS: p < 0.001
- Total cost: p = 0.005
- VAS pain score: p < 0.001
- VAS pain score: p < 0.001
- VAS pain score: p < 0.001
- VAS pain score: p < 0.001
Original publication
Perioperative liberal drinking management promotes postoperative gastrointestinal function recovery after gynecological laparoscopic surgery: A randomized controlled trial. J Clin Anesth. Published 29 June 2024. doi:10.
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