Perioperative opioid prescribing and iatrogenic opioid use disorder and overdose: a state-of-the-art narrative review
Authors' conclusion
Retrospective data suggest an incidence of new postoperative OUD and overdose of up to 0.8% during the first year after surgery, but prospective studies are lacking.
Study context
- Population
- Surgical patients receiving perioperative opioids (evidence mainly from insurance claims and Veterans Health Administration data)
- Outcome
- New postoperative opioid use disorder (OUD) and overdose
- Follow-up
- First year after surgery
Methodological detailsstate-of-the-art
- State-of-the-art
Main finding
As reported in the abstract
New postoperative OUD and overdose
Incidence of new opioid use disorder (OUD)
0.1% to 0.8%
Rate of overdose events
0.01% to 0.8%
Further findings
Risk factors for postoperative OUD and overdose
- Substance use: preoperative opioid use; non-opioid substance use disorders; preoperative sedative, anxiolytic, antidepressant and gabapentinoid use; postoperative new persistent opioid use
- Demographics: chiefly male sex, younger age, white race, Medicaid or no insurance
- Psychiatric comorbidities (depression, bipolar disorder, PTSD) and certain medical and surgical factors
Original publication
Perioperative opioid prescribing and iatrogenic opioid use disorder and overdose: a state-of-the-art narrative review. Reg Anesth Pain Med. Published 6 November 2023. doi:10.
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