Perioperative pain management with regional analgesia techniques for visceral cancer surgery: A systematic review and meta-analysis
Authors' conclusion
Following visceral cancer surgery EA may reduce pain intensity. In contrast, PRA had only limited effects on pain intensity at rest and during activity. However, we are uncertain regarding the effect of both techniques on block-related adverse events and paralytic ileus.
Study context
- Population
- Adults undergoing visceral cancer surgery
- Participants
- 4,345 adults · 59 RCTs
- Comparison
- Peripheral regional analgesia (peripheral (PRA)) or epidural analgesia (EA) vs systemic analgesia (SA)
- Outcome
- Acute pain intensity at rest and during activity; patients with block-related adverse events; postoperative paralytic ileus
- Follow-up
- 24 h after surgery
Methodological detailsGRADE assessment
- GRADE assessment
Pooled result
As reported in the abstract
Pain intensity
Each group vs SAMD (95% CI)
EAat rest; low certainty evidence
−1.05(−1.35 to −0.75)
EAduring activity; very low certainty evidence
−1.83(−2.34 to −1.33)
PRAat rest; moderate certainty evidence
−0.75(−1.20 to −0.31)
PRAduring activity; moderate certainty evidence
−0.93(−1.34 to −0.53)
Safety
Block-related adverse events
- May be no difference between EA, respectively PRA and SA (very low certainty evidence)
Original publication
Perioperative pain management with regional analgesia techniques for visceral cancer surgery: A systematic review and meta-analysis. J Clin Anesth. Published 14 March 2024. doi:10.
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