Perioperative medicine & outcomes
Perioperative Plasma in Addition to Red Blood Cell Transfusions Is Associated With Increased Venous Thromboembolism Risk Postoperatively
Main finding · Postoperative VTEResult — go to the resultRelative risk 1.36 95% CI 1.24–1.49Authors' conclusion
When compared with perioperative RBC transfusion, adding plasma was associated with increased 30-day postoperative mortality, VTE, PE, and DIC risk among surgical and cardiovascular surgical patients.
Study context
- Population
- Surgical patients receiving perioperative red blood cell (RBC) transfusion, incl. cardiovascular surgeriesall surgeries
- Participants
- 48,580 patients
- Exposure
- Perioperative plasma + RBC vs RBC only
- Outcome
- Postoperative venous thromboembolic (VTE)
Methodological detailspropensity-score matched, US claims and EHR database (TriNetX Diamond Network)
- Propensity-score matched
- US claims and EHR database (TriNetX Diamond Network)
Main finding
As reported in the abstract
Relative risk
1.36
95% CI 1.24–1.49
By group
Plasma + RBC vs RBC
RR 1.36 (95% CI 1.24–1.49)
Observational data: associations, not effects.
Further findings
30-day postoperative mortality
| Outcome | Plasma + RBC | RBC | RR (95% CI) | |
|---|---|---|---|---|
| PE | 1.94% | 1.33% | 1.46 (1.26–1.68) | |
| Disseminated intravascular coagulation (DIC) | 0.96% | 0.35% | 2.75 (2.15–3.53) | |
| 0.20.5125Relative risk (log scale) |
Cardiovascular surgeries (subgroup; n = 38,918)
- Adding plasma to RBC associated with similar increased risk
Original publication
Perioperative Plasma in Addition to Red Blood Cell Transfusions Is Associated With Increased Venous Thromboembolism Risk Postoperatively. Anesth Analg. Published 28 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →