Hemodynamics, fluids & transfusion
Implications of packed red bloods cells production and transfer on post transfusion hemoglobin increase
Authors' conclusion
The aspired increase in hemoglobin can be achieved with red blood cell concentrates of any storage duration.
Study context
- Population
- Patients older than 70 years who underwent non-cardiac surgery and received red blood cell (RBC) transfusions, surgical cohorts of the LIBERAL-Trial1,626 transfusion events
- Participants
- 505 participants
- Exposure
- RBC unit storage duration
- Outcome
- Hemoglobin increment upon RBC transfusion
Methodological detailslinear mixed effects model, two study sites, Transfusion events and Hb assessments 2018–2022 with manufacturing and product-specific quality review information
- Linear mixed effects model
- Two study sites
- Transfusion events and Hb assessments 2018–2022 with manufacturing and product-specific quality review information
Main finding
As reported in the abstract
Hemoglobin increment by RBC storage duration
- No statistically significant effect of RBC unit storage duration
Observational data: associations, not effects.
Further findings
Other predictors of hemoglobin increment
- Higher Hb increase with lower pre-transfusion Hb, length of Hb measurement intervals before and after transfusion, and method of RBC cell separation (different manufacturer Hb values)
Original publication
Implications of packed red bloods cells production and transfer on post transfusion hemoglobin increase. J Clin Anesth. Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →