Hemodynamics, fluids & transfusion
Transfused Red Blood Cell Characteristics and Kidney Transplant Outcomes Among Patients Receiving Early Posttransplant Transfusion
An erratum to this article was published (JAMA Netw Open, 2 Oct 2023 ↗)
Main finding · Transplant failure per additional RBC storage dayResult — go to the resultHazard ratio 0.99 95% CI 0.98–1.00Authors' conclusion
In this study, longer RBC storage duration was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions.
Study context
- Population
- Recipients of a first kidney transplant in France, 2002–2008, who received RBC transfusion during the first 14 days posttransplanttransfused, of 12,559 transplanted
- Participants
- 3,483 recipients
- Exposure
- Longer vs shorter storage duration of transfused RBC
- Outcome
- Transplant failure (graft loss or death with a functional graft)
Methodological detailsnationwide, registry linkage, multivariable Cox proportional hazards regression, Median (IQR) follow-up 7.8 (7.6-8.0) years, Median (IQR) age 53.0 (41.5-61.2) years; 1929 (55.4%) male
- Nationwide
- Registry linkage
- Multivariable Cox proportional hazards regression
- Median (IQR) follow-up 7.8 (7.6-8.0) years
- Median (IQR) age 53.0 (41.5-61.2) years; 1929 (55.4%) male
Main finding
As reported in the abstract
Transplant failure per additional RBC storage day
Hazard ratio
0.99
95% CI 0.98–1.00
P = 0.06
Longer storage (per additional day) vs Shorter storage
HR 0.99 (95% CI 0.98–1.00); P = 0.06
Observational data: associations, not effects.
Further findings
Absolute decrease in transplant failure, stored >20 days vs <20 days · 3 and 5 years
- Absolute decrease in transplant failure at 3 years
- 5%
- Absolute decrease in transplant failure at 5 years
- 7%
Original publication
Transfused Red Blood Cell Characteristics and Kidney Transplant Outcomes Among Patients Receiving Early Posttransplant Transfusion. JAMA Netw Open. Published 5 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →