Hemodynamics, fluids & transfusion
Association Between Length of Storage of Transfused Packed RBC Units and Outcome of Surgical Critically Ill Adults: A Subgroup Analysis of the Age of Blood Evaluation Randomized Trial*
Primary resultResult — go to the resultAbsolute risk difference 0.01 95% CI −0.09 to 0.11Authors' conclusion
There was no evidence that fresh red cells improved outcomes as compared to standard issue red cells in critically ill surgical patients, consistent with other patients enrolled in the ABLE trial.
Study context
- Population
- Surgical nontrauma critically ill adults in ICU with a first RBC transfusion request in the first week and anticipated mechanical ventilation ≥48 hours; elective cardiac surgery and trauma excludedof 2,510 ABLE ICU adults
- Participants
- 320 adults
- Comparison
- Fresh RBC units vs standard issue RBC
- Freshn = 172
- Standardn = 148reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 90 days
Methodological detailssubgroup analysis
- Subgroup analysis
Primary result
As reported in the abstract
Absolute risk difference
0.01
95% CI −0.09 to 0.11
P = 0.803
By group
Fresh vs Standard
absolute risk difference 0.01 (95% CI −0.09 to 0.11); P = 0.803
Secondary outcomes
Length of storage
P < 0.0001
All secondary outcomes, incl. 6-month mortality
- No significant differences, even after adjustment for age, country and APACHE score
Original publication
Association Between Length of Storage of Transfused Packed RBC Units and Outcome of Surgical Critically Ill Adults: A Subgroup Analysis of the Age of Blood Evaluation Randomized Trial*. Crit Care Med. Published 27 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →