Perioperative medicine & outcomes
Perioperative polygenic and apolipoprotein E (APOE)-based genetic risk assessment for neurocognitive disorders: a biobank study
Authors' conclusion
APOE genotypes and polygenic risk scores are valuable for exploring neurocognitive genetic risk profiles in surgical populations
Study context
- Population
- Male and female surgical patients aged 40–89 yr without previous Alzheimer's disease diagnosis, Mass General Brigham Biobank86% European ancestry
- Participants
- 33,526 participants
- Exposure
- APOE-ε4 carriers and Alzheimer's disease polygenic risk score vs neurocognitive disorders
- Outcome
- Neurocognitive disorders
Methodological detailsbiobank
- Biobank
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Polygenic risk score for Alzheimer's diseaseAlzheimer's disease; European ancestry
2.25(1.64–3.09)
FDR <0.001APOE-ε4delirium
1.32(1.19–1.47)
FDR <0.001APOE-ε4mild cognitive impairment
1.70(1.49–1.94)
FDR <0.001APOE-ε4Alzheimer's disease
3.42(2.72–4.29)
FDR <0.001Observational data: associations, not effects.
Original publication
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study. Br J Anaesth. Published 24 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →