Perioperative medicine & outcomes
Perioperative thrombin generation and fibrinolytic activation in patients undergoing major gynaecologic surgery for benign and malignant pathology: a pilot study
Authors' conclusion
In this pilot study, perioperative fibrinolytic activation was similar between malignant and benign gynaecological surgery, whereas malignancy was associated with altered TG kinetics.
Study context
- Population
- Patients undergoing major gynaecological surgery, June–November 202412 laparoscopic
- Participants
- 13 patients
- Exposure
- Malignant vs benign pathology in major gynaecological surgery
- Malignantn = 6
- Benignn = 7reference
- Outcome
- Perioperative changes in fibrinolysis and thrombin generation (TG) and their trajectories, malignant vs benign
Methodological detailssingle-centre, exploratory
- Single-centre
- Exploratory
Main finding
As reported in the abstract
Thrombin generation kinetics, malignant vs benign pathology (linear mixed-effects models)
Malignancy associated with longer lag time
β 3.11 min
95% CI 0.67–5.56
Malignancy associated with lower peak thrombin
β −84.1 nM
95% CI −163.5 to −4.8
Observational data: associations, not effects.
Original publication
Perioperative thrombin generation and fibrinolytic activation in patients undergoing major gynaecologic surgery for benign and malignant pathology: a pilot study. BJA Open. Published 29 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →